Beta-lactam Allergy
Allergy Types

Allergy Types

Allergy Types

Mediated by IgE antibodies

Onset usually within 1 hour (up to 24h)

Cross-reactivity information useful

Skin Testing useful

Mediated by IgG or IgM antibodies

Onset usually >72 hours (up to 14 days)

Reaction is drug specific

Cross-reactivity information is not useful

Offending drug is contraindicated

Mediated by antigen-antibody complexes

Onset usually >72 hours (up to 14 days)

Cross-reactivity information is lacking

If severe (e.g. AIN), all beta-lactams are considered contraindicated unless guided by an expert

Mediated by T-cells

Onset usually >72 hours (up to 3-4 weeks)

Cross-sensitivity is possible but not predictable by skin testing or oral challenge

If severe (e.g. SJS), all beta-lactams are considered contraindicated unless guided by an expert