Intravenous (IV) to oral (PO) administration of antimicrobials help increase patient mobility and reduces the chance of secondary IV line complications such as thrombophlebitis.
With appropriate IV to PO conversion, there is no difference in treatment success or mortality.
Assess for PO conversion using established criteria.
Clinical pharmacists will review and change route of antimicrobial administration using established criteria.
Continues to require antimicrobials AND
Is clinically stable AND
Is able to tolerate oral medications AND
Has no factors affecting oral absorption (e.g., presence of gastrointestinal abnormalities or drug interactions)
Anti-infectives which are equivalent given IV or PO
Similar drug levels achieved with oral dosage form of same drug
Step-down to similar PO drug
Guideline adapted from Providence Health Care, Vancouver