Surgical intervention is the major therapeutic modality
Ceftriaxone 2 g IV q24h
OR
Cefotaxime 2 g IV q6-8h
Ceftazidime 2 g IV q8h
PLUS
Doxycycline 100 mg PO q12h
Tetracycline 500 mg PO q6h
Ciprofloxacin 400 mg IV q12h
Levofloxacin 750 mg PO q24h
V. vulnificus (seafood ingestion)
A. hydrophila (freshwater fish ingestion)