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Cholangitis, acute

Cholangitis, acute

Empiric Antimicrobial Therapy

Community-acquired, mild
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Mild cases do not meet the criteria of grade II-III (moderate to severe) acute cholangitis at initial diagnosis

Community-acquired, moderate
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Moderate cases are defined as at least 2 of the following conditions:

  • WBC >12,000 or <4,000/mm³
  • BT ≥39C
  • age ≥75y
  • total bilirubin ≥5 mg/dL
  • albumin < standard deviation x 0.7

Community-acquired, severe
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Severe cases are defined as at least 1 of any of the following conditions:

  • hypotension requiring dopamine ≥5 μg/kg/min, or any dose of norepinephrine
  • disturbance of consciousness
  • PaO2 / FiO2 <300
  • oliguria or serum creatinine >2.0 mg/dL
  • prothrombin time (INR) >1.5
  • platelet <100,000 /mm³