Salmonella typhi

Aerobic, gram-negative rod.

Humans are the reservoir - fecal-oral transmission.

Increased prevalence in developing countries.

Highest prevalence in South Asia.

• Fever in Returning Traveler

• Enteric fever

• FUO (Fever of Unknown Origin)

• Bacteremia

• Intra-abdominal abscess

• Meningitis

• Endovascular infection including endocarditis and infected atherosclerotic plaque/aneurysm - "sticky" organism

Very high rates of FQ resistance in the Indian subcontinent.

Vaccination only prevents ~75% of disease.

Chronic carriage associated with gallbladder disease.