Neisseria gonorrhoeae


Standard Precautions

General Information

Gram-negative diplococci.

Gonorrhea is quickly developing resistance to cephalosporins and fluoroquinolones.

Sexually transmitted disease that infects the mucous membranes of the reproductive tract, including cervix, uterus, and fallopian tubes in women, and the urethra in women and men. It can also infect the mucous membranes of the mouth, throat, eyes, and rectum.

Gonorrhea can also be spread perinatally from mother to baby during childbirth.

Most infected people are asymptomatic.

  • Pelvic inflammatory disease (PID)

  • Internal abscess

  • Infertility

  • Ectopic pregnancy

  • Epididymitis

  • Disseminated gonococcal infection (DGI)

  • Pharyngeal infection

Nucleic acid amplification testing (NAAT) used to test urine, urethral, or cervical discharge. Also can use isolation of organism in culture of urethra, cervix, blood, pharynx, or joint fluid for testing.

Development of antimicrobial resistance is of increasing concern. 2020 US CDC Guidelines recommend Ceftriaxone IM for uncomplicated gonorrhea.

Sancta St. C et al. Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1911–1916.

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