Cefuroxime

제한된
0
C. difficile 위험도
Medium
경구생체이용률
Moderate

Dosing

Pharyngitis, tonsillitisAcute maxillary sinusitisAECBUncomplicated SSTIUncomplicated UTIUncomplicated gonorrheaEarly Lyme diseaseIV 없음, PO 만 있음250 mg PO q12h x10d200 mg PO q12h x10d250-500 mg PO q12h x10d250-500 mg PO q12h x10d250 mg PO q12h x7-10d1 g PO (single dose)500 mg PO q12h x20dNo data on renal dose adjustment

Safety and efficacy in pediatric patients ≤3m of age have not been established

Cefuroxime axetil tablet is not bioequivalent with Cefuroxime axetil suspension

Acute otitis mediaAcute maxillary sinusitis250 mg PO q12h x10d250 mg PO q12h x10d

Pharyngitis, tonsillitisAcute otitis media, Acute maxillary sinusitisImpetigo20 mg/kg PO #2 (max 500 mg/dose) x10d30 mg/kg PO #2 (max 1 g/dose) x10d30 mg/kg PO #2 max 1 g/dose) x10d

No data on renal dose adjustment

No dose adjustment

General Information

  • Acute bacterial exacerbation of chronic bronchitis

  • Acute otitis media

  • Uncomplicated gonorrhea

  • Impetigo

  • Infection of skin and/or subcutaneous tissue, uncomplicated

  • Lyme disease, early

  • Acute maxillary sinusitis

  • Pharyngitis

  • Tonsillitis

  • Uncomplicated urinary tract infection

Monitor CBC, renal function, fever, prothrombine time in patients at risk.

Common

  • Diarrhea

  • Nausea

  • Vomiting

  • Vaginitis

Serious

  • Erythema multiforme

  • Stevens-Johnson syndrome

  • Topic epidermal necrolysis

  • Anaphylaxis

  • Hypersensitivity reaction

Avoid concomitant use:

  • Histamine-2 (H-2) antagonists and proton pump inhibitors

  • Probenecid

Major drug-drug interactions:

  • Combination oral contraceptives

  • Cholera vaccine, live

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions:

  • Discontinuation may be necessary in Clostridium difficile-associated diarrhea.

  • Use caution in patients with history of gastrointestinal disease, especially colitis.

  • Discontinue if hypersensitivity reaction occurs.

  • A false-positive result for urine glucose may occur with copper reduction tests, and a false negative result for blood/plasma glucose may occur with ferricyanide tests.

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