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항생제
Cefuroxime

Cefuroxime

Medium
Moderate

Spectrum Of Activity

General Spectrum of Activity
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General Information

  • Acute bacterial exacerbation of chronic bronchitis
  • Acute otitis media
  • Uncomplicated gonorrhea
  • Impetigo
  • Infection of skin and/or subcutaneous tissue, uncomplicated
  • Lyme disease, early
  • Acute maxillary sinusitis
  • Pharyngitis
  • Tonsillitis
  • Uncomplicated urinary tract infection

Monitor CBC, renal function, fever, prothrombine time in patients at risk.

Common

  • Diarrhea
  • Nausea
  • Vomiting
  • Vaginitis

Serious

  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Topic epidermal necrolysis
  • Anaphylaxis
  • Hypersensitivity reaction

Avoid concomitant use:

  • Histamine-2 (H-2) antagonists and proton pump inhibitors
  • Probenecid

Major drug-drug interactions:

  • Combination oral contraceptives
  • Cholera vaccine, live

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions:

  • Discontinuation may be necessary in Clostridium difficile-associated diarrhea.
  • Use caution in patients with history of gastrointestinal disease, especially colitis.
  • Discontinue if hypersensitivity reaction occurs.
  • A false-positive result for urine glucose may occur with copper reduction tests, and a false negative result for blood/plasma glucose may occur with ferricyanide tests.