C. difficile 위험도


CAP, SSTIGastrointestinal or genitourinary tract infectionBacterial meningitis, bacteremia250-500 mg IV q6h500 mg IV q6h2 g IV q4h (max 12 g/d)

CAPGastrointestinal or genitourinary tract infection250 mg PO q6h500 mg PO q6h

CAP, SSTIGastrointestinal or genitourinary tract infectionBacterial meningitis, bacteremia25-50 mg/kg IV #3-450 mg/kg IV #3-4150-200 mg/kg IV #6 (max 12 g/d)If BW >40 kg, refer to adult dose

CAPGastrointestinal or genitourinary tract infection50 mg/kg PO #3-4100 mg/kg PO #3-4 (max 2 g/d)If BW >20 kg, refer to adult dose

No dose adjustment

CrCl >50CrCl 10-50CrCl <10HDCRRTRecommended dose at recommended intervalsRecommended dose IV/PO q8hRecommended dose IV/PO q12h1-2 g q12h (give one of the dialysis day doses AD)1-2 g q8-12h

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Monitor CBC, hematopoietic, hepatic and renal function.

When treating chronic urinary tract and intestinal infections, perform serological tests and monitor clinical response.

Perform serological tests in all cases where concomitant syphilis is suspected.


  • Rash

  • Urticaria

  • Diarrhea


  • Erythema multiforme

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Clostridium difficile colitis

  • Agranulocytosis

  • Thrombocytopenia

  • Anaphylaxis

  • Hypersensitivity reaction

  • Allopurinol- increased rash

  • Warfarin- increased risk of bleeding

  • Tetracyclines

  • Seizure threshold lowering agents

  • Cholera vaccine, live

  • Oral contraceptives

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions: Give cautiously to patients with history of hypersensitivity to multiple allergens due to increased risk of serious and potentially fatal hypersensitivity reaction.

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