General Spectrum of Activity
Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate.
Check urine for crystals if AKI suspected.
Antimicrobial class: Antiviral agent, Nucleoside analogue
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic
Urine penetration: Therapeutic
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.