항생제
Amoxicillin/Clavulanate

Amoxicillin/Clavulanate

Medium
Excellent

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Monitor CBC.

Perform culture and susceptibility tests during treatment.

During prolonged therapy, monitor renal, hepatic and hematopoietic functions.

Common

  • Rash
  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Vaginitis
  • Mycosis
  • Candidiasis

Serious

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Cholestasis
  • Hepatitis
  • Hepatotoxicity
  • Anaphylaxis
  • Hypersensitivity reaction

Multiple drug-drug interactions

  • Allopurinol - increased rash
  • Probenecid

Antimicrobial class: Aminopenicillin, Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions:

  • Dose adjustment necessary in severe renal impairment.
  • Use caution in patients with hepatic impairment due to risk of toxicity.
  • Discontinuation may be required in Clostridium difficile-associated diarrhea or anaphylactic reactions occur.
  • Avoid use in patients with monocleosis due to increased risk for erythematous skin rash.