Meropenem

제한된
1
C. difficile 위험도
Medium
경구생체이용률
N/A

Dosing

Complicated SSTIPseudomonas aeruginosa infectionComplicated intraabdominal infectionBacterial meningitis500 mg IV q8h1 g IV q8h1 g IV q8h2 g IV q8h

Complicated SSTIP. aeruginosa infectionComplicated intraabdominal infectionBacterial meningitisAge ≥3m: 10 mg/kg IV q8h (max 500 mg/dose)20 mg/kg IV q8h (max 1 g/dose)20 mg/kg IV q8h (max 1 g/dose) Age ≥3m: 40 mg/kg IV q8h (max 2 g/dose)

No dose adjustment

CrCl >50CrCl 26-50CrCl 10-25CrCl <10HDCRRTNo dose adjustmentRecommended dose IV q12h50% recommended dose IV q12h50% recommended dose IV 24h500 mg q24h (give dialysis day dose AD)1 g q12h

General Information

Therapy of serious, often nosocomial infections involving resistant gram-negative organisms

Monitor hematopoietic, renal, and hepatic function, periodically during prolonged therapy.

Common

  • Rash

  • Diarrhea

  • Constipation

  • Nausea

  • Anemia

  • Headache

  • Injection site inflammation

Serious

  • Myocardiac infarction

  • Heart failure

  • Syncope

  • Shock

  • Bowel obstruction

  • Clostridium difficile diarrhea

  • Hemorrhage

  • Cholestatic jaundice syndrome

  • Jaundice

  • Liver failure

  • Seizure

  • Renal failure

  • Hypoxia

  • Pleural effusion

  • Pulmonary edema

  • Pulmonary embolism

  • Sepsis

  • Angioedema

  • Anaphylaxis

  • Hypersensitivity reaction

  • Valproic acid - may result in decreased plasma concentrations and loss of anticonvulsant effect

  • Cholera vaccine, live

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic

Precautions:

  • If signs and symptoms of severe cutaneous adverse reactions appear, immediately discontinue and consider alternative.

  • Dose reduction or discontinuation and anticonvulsant therapy may be necessary if focal tremors, myoclonus, or seizures occur.

  • Discontinue if allergic reaction occurs.

  • Neuromotor impairment may occur; use with caution in outpatients.

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