Primary Sepsis
Meropenem

Meropenem

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Medium
N/A

General Information

Therapy of serious, often nosocomial infections involving resistant gram-negative organisms

Monitor hematopoietic, renal, and hepatic function, periodically during prolonged therapy.

Common

  • Rash
  • Diarrhea
  • Constipation
  • Nausea
  • Anemia
  • Headache
  • Injection site inflammation

Serious

  • Myocardiac infarction
  • Heart failure
  • Syncope
  • Shock
  • Bowel obstruction
  • Clostridium difficile diarrhea
  • Hemorrhage
  • Cholestatic jaundice syndrome
  • Jaundice
  • Liver failure
  • Seizure
  • Renal failure
  • Hypoxia
  • Pleural effusion
  • Pulmonary edema
  • Pulmonary embolism
  • Sepsis
  • Angioedema
  • Anaphylaxis
  • Hypersensitivity reaction
  • Valproic acid - may result in decreased plasma concentrations and loss of anticonvulsant effect
  • Cholera vaccine, live

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic

Precautions:

  • If signs and symptoms of severe cutaneous adverse reactions appear, immediately discontinue and consider alternative.
  • Dose reduction or discontinuation and anticonvulsant therapy may be necessary if focal tremors, myoclonus, or seizures occur.
  • Discontinue if allergic reaction occurs.
  • Neuromotor impairment may occur; use with caution in outpatients.