항생제
Linezolid

Linezolid

제한된

Low
Excellent

General Information

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.

Covers MRSA and VRE.

Monitor CBC weekly; blood pressure; signs and symptoms of serotonin syndrome.

Perform visual function tests for therapy >3 months or if symptoms develop during therapy.

Common

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache

Serious

  • Lactic acidosis
  • Clostridioides difficile infection
  • Myelosuppression
  • Injury of liver
  • Peripheral neuropathy
  • Seizure
  • Optic nerve disorder
  • Serotonin syndrome
  • SSRI and other serotonergics/MAOIs: increased risk of serotonin syndrome
  • Rifampin: decreases linezolid levels

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions:

  • Use not recommended unless patients monitored for potential blood pressure increases.
  • Use not recommended in patients with CNS infections or catheter-related bloodstream infections/catheter-site infections.
  • Monitoring recommended for ophthalmic changes.