제한된
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Black Box Warning:
Monitor renal and liver functions; serum electrolytes (K and Mg levels).
Evaluate CBC and hemoglobin concentrations.
Monitor and record temperature, pulse, respiration, and blood pressure every 30 minutes for 2-4 hours following a single IV test dose.
Monitor pulmonary function in patients with recent or concomitant leukocyte transfusion.
Close clinical observation by medically trained personnel is recommended during infusion.
Infusion-related symptoms
Electrolyte abnormalities -
Antimicrobial class: Antifungal, Polyene
Pregnancy category: B
Average serum half life: 24 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Premedication with acetaminophen, diphenhydramine or hydrocortisone are used. Meperidine may be used for rigors.
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN.