항생제
Azithromycin

Azithromycin

Medium
Moderate

Spectrum Of Activity

General Information

  • Community-acquired pneumonia
  • Pertussis
  • Upper respiratory tract infections
  • Chlamydial infections
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients

Monitor QTc in patients with increased risk.

Common

  • Abdominal pain
  • Diarrhea
  • Flatulence
  • Nausea
  • Vomiting
  • Headache
  • Abnormal vision
  • Increased liver enzymes
  • Injection site reaction

Serious

  • Prolonged QT interval
  • Torsades de pointes
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Generalized exanthematous pustulosis, acute
  • Congenital hypertrophic pyloric stenosis
  • Hepatitis
  • Liver failure
  • Hepatic necrosis
  • Maysthenia gravis
  • Exacerbation of myasthenic crisis
  • Eaton-Lambert syndrome
  • Corneal erosion
  • Increases cyclosporine levels
  • May increase digoxin levels
  • Statins increased risk of rhabdomyolysis

Contraindication:

  • QT interval prolonging drugs

Multiple drug-drug interactions

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing (e.g. Salmonella species).