Higher doses (150 mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.
Not recommended in renal imapirment (ESRD not undergoing dialysis).
Discontinue use if allergic-like reaction occurs.
One dose delivers 2 g of sorbitol and may cause dyspepsia or diarrhea in patients with hereditary fructose intolerance.
Abnormal behavior and delirium leading to potentially fatal injuries may occur, primarily in pediatric patients.