Doxycycline

제한된
0
C. difficile 위험도
Low
경구생체이용률
Excellent

Dosing

Usual doseSevere infection (chronic genitourinary tract infection)Scrub typhusUncomplicated gonococcal infectionUncomplicated C. trachomatis urethral, endocervical, rectal infectionC. trachomatis or U. urealyticum urethritisEarly syphilis in penicillin-allergic patientsLate latent syphilis in penicillin allergic patientsN. gonorrhea or C. trachomatis acute epididymo-orchitisMalaria prophylaxis100 mg PO q12h 2 doses, then 100 mg PO q24h100 mg PO q12h100 mg PO q12h x7d100 mg PO q12h x7d100 mg PO q12h x7d100 mg PO q12h x7d100 mg PO q12h x2w100 mg PO q12h x4w100 mg PO q12h x≥10d100 mg PO q24h from 1-2d before traveling to 4w after leaving malarious areaNo renal dose adjustment

IV 없음, PO 만 있음

Safety and efficacy in pediatric patients ≤8y of age have not been established- Age >8y 4.4 mg/kg PO #2 x1d, then 2.2 mg/kg PO #2

  • BW > 45 kg Refer to adult doseNo renal dose adjustment

No dose adjustment

General Information

  • Skin and soft tissue infection

  • Community-acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • MRSA infections

Monitor diarrhea, CBC, liver and kidney function tests.

Blood serology monthly for a minimum of 4 months during venereal disease treatment with suspected syphilis infection.

Common

  • Diarrhea

  • Photosensitivity

  • Nasopharyngitis

Serious

  • Erythema multiforme

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Drug reaction with eosinophilia and systemic symptoms

  • Clostridium difficile diarrhea

  • Hepatotoxicity

  • Hypersensitivity reaction

  • Pseudotumor cerebri

Major drug-drug interactions:

  • Penicillins

  • Ascorbic acid

  • Retinoids

  • Methotrexate - risk of toxicity

  • Methoxyflurane

  • Porfimer and photosensitizing agents

  • Combination oral contraceptives

Contraindication:

  • Acitretin: increased risk of pseudotumor cerebri

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

Precautions:

  • Discontinue of Clostridium difficile-associated diarrhea or skin erythema occurs.

  • Use during tooth development may cause permanent tooth discoloration.

  • Premature infants are at increased risk for a decrease in fibula growth rate at oral doses of 25 mg/kg every 6 hours; reversible upon discontinuation.

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