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항생제
Doxycycline

Doxycycline

Low
Excellent

Spectrum Of Activity

General Spectrum of Activity
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General Information

  • Skin and soft tissue infection
  • Community-acquired pneumonia
  • Malaria prophylaxis
  • Zoonoses
  • MRSA infections

Monitor diarrhea, CBC, liver and kidney function tests.

Blood serology monthly for a minimum of 4 months during venereal disease treatment with suspected syphilis infection.

Common

  • Diarrhea
  • Photosensitivity
  • Nasopharyngitis

Serious

  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Drug reaction with eosinophilia and systemic symptoms
  • Clostridium difficile diarrhea
  • Hepatotoxicity
  • Hypersensitivity reaction
  • Pseudotumor cerebri

Major drug-drug interactions:

  • Penicillins
  • Ascorbic acid
  • Retinoids
  • Methotrexate - risk of toxicity
  • Methoxyflurane
  • Porfimer and photosensitizing agents
  • Combination oral contraceptives

Contraindication:

  • Acitretin: increased risk of pseudotumor cerebri

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

Precautions:

  • Discontinue of Clostridium difficile-associated diarrhea or skin erythema occurs.
  • Use during tooth development may cause permanent tooth discoloration.
  • Premature infants are at increased risk for a decrease in fibula growth rate at oral doses of 25 mg/kg every 6 hours; reversible upon discontinuation.