Spectrum Of Activity
750 mg PO q24h
Safety and efficacy in pediatric patients <18y of age have not been established
No dose adjustment
CrCl >50CrCl 10-50CrCl <10HDCRRTNo dose adjustment750 mg PO q24-48h250 mg PO q48h(a) when normal dose is 750 mg q24h : 750 mg once, then 500 mg q48h (b) when normal dose is 500 mg q24h : 500 mg once, then 250 mg q48h
TB : 750-1,000 mg PO/IV 3 times/week750 mg once, then 500 mg q48h
Lower respiratory infection (CAP, HAP)
Black Box Warning:
Discontinue levofloxacin and avoid use of fluoroquinolones in patients with these serious adverse reactions.
Reserve use of levofloxacin for patients with no alternative treatment options for an uncomplicated UTI, acute bacterial exacerbation of chronic bronchitis, or acute bacterial sinusitis.
Avoid in patients with known history of myasthenia gravis.
Monitor QTc in patients with increased risk.
Monitor WBC counts and follow culture and susceptibility tests during treatment.
Obtain acid-fast bacilli (AFB) smear and culture from sputum at least monthly until 2 consecutive culture specimens are negative.
Monitor CBC with differential, renal and liver function tests, blood glucose, and serum electrolytes.
Prolonged QT interval
Trosades de pointes
Rupture of tendon
Acute renal failure
Other QTc prolonging agents
Divalent cations - decreased absorption
NSAIDs - increase seizure risk
Warfarin - increased INR
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 7 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
Avoid use with known QT prolongation, uncorrected hypokalemia, and with Class IA or Class III antiarrhythmic agents.
Avoid use patients at risk for developing aortic aneurysm (unless alternative treatment is unavailable) and discontinue treatment if aortic aneurysm or dissection is suspected or occurs.
Discontinue of signs and symptoms of hepatitis, hypersensitivity reactions, psychiatric reactions or CNS adverse reactions occur.
Use caution in patients with renal dysfunction or renal failure due to risk of seizures and tendon rupture.
Micromedex web. Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2019 October 15]. Available from: Micromedex