Micafungin

제한된
1
C. difficile 위험도
Low
경구생체이용률
N/A

Dosing

Candidemia, disseminated candidiasisEsophageal candidiasisCandida infection prophylaxis in HSCT patients100 mg IV q24h150 mg IV q24h50 mg IV q24hNo renal dose adjustment

Candidemia or disseminated candidiasisEsophageal candidiasisCandida infection prophylaxis in HSCT patientsSafety and effectiveness in pediatric patients <4m of age have not been established2 mg/kg IV q 24h (max 100 mg/dose)- BW ≤30 kg: 3 mg/kg IV q24h

  • BW >30 kg: 2.5 mg/kg IV q24h (max 150 mg/dose)1 mg/kg IV q24h (max 50 mg/dose) No renal dose adjustment

No dose adjustment

General Information

  • Candidemia

  • Candidiasis of the esophagus

  • Candidiasis of the esophagus - HIV infection

  • Invasive candidiasis

  • Invasive candidiasis, Hematopoietic Stem Cell Transplantation; Prophylaxis

  • Invasive candidiasis, Peritonitis or abscess

Common

  • Acidosis

  • Hypokalemia

  • Diarrhea

  • Nausea

  • Vomiting

  • Thrombocytopenia

  • Headache

  • Fever

  • Sepsis

Serious

  • Atrial fibrillation

  • Anemia

  • Hemoglobinuria

  • Hemolysis

  • Hepatitis

  • Anaphylaxis

  • Acute renal failure

  • Sirolimus

  • Nifedipine

  • Itraconazole

Antimicrobial class: Antifungal, Echinocandin

Pregnancy category: C

Average serum half life: 15 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

Precautions:

  • Discontinue if hypersensitivity reactions occur.

  • Slow infusion rate if reaction occurs.

  • Significant hemolysis and renal dysfunction have been reported.

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