Monitor creatinine at least 3 times/week; discontinue if any signs of ototoxicity.
For multiple daily dosing: Target peak 4-10 ug/mL, Trough 1-2 ug/mL.
For once daily: Target trough <1 ug/mL
NB: Trough level is 0-60 min before a dose (usually pre-4th), and peak is 30-60 min after dose infused (usually post-3rd).
In critically ill patients, check peak level after the first dose as volume of distribution and renal function may change rapidly.