General Spectrum of Activity
Candida infections that are both mucocutaneous and invasive - i.e. Candidemia.
Cryptococcus and Coccidioides infections.
Antifungal prophylaxis in immunocompromised.
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.
Monitor renal function, abnormal liver function, rash progression.
Many via CYP450. Suggest review specific patient medications.
Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.
Risk when combining with other QTc prolonging medications.
Multiple drug-drug interactions
Antimicrobial class: Antifungal, Triazole
Pregnancy category: C
Average serum half life: 20-50 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Therapeutic
Micromedex web. Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2019 October 15].
Available from: Micromedex