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항생제
Fluconazole

Fluconazole

Low
Excellent

Spectrum Of Activity

General Spectrum of Activity
​

General Information

Candida infections that are both mucocutaneous and invasive - i.e. Candidemia.

Cryptococcus and Coccidioides infections.

Antifungal prophylaxis in immunocompromised.

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

Monitor renal function, abnormal liver function, rash progression.

Common

  • Nausea
  • Vomiting
  • Headache

Serious

  • Prolonged QT interval
  • Torsades de pointes
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Agranulocytosis
  • Anaphylaxis
  • Seizure

Many via CYP450. Suggest review specific patient medications.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.

Multiple drug-drug interactions

Antimicrobial class: Antifungal, Triazole

Pregnancy category: C

Average serum half life: 20-50 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic

Precautions:

  • Caution advised with use in patients with potentially proarrhythmic conditions.
  • Monitoring recommended in patients with liver dysfunction and discontinue if signs of liver disease develop.
  • Use caution in patients with hypersensitivity to other azole antifungal agents; cross-hypersensitivity not yet determined.

Micromedex web. Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2019 October 15]. Available from: Micromedex