Broad gram-negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram-positive activity versus other cephalosporins.
Monitor renal function in elderly patients, and when administered concomitantly with aminoglycoside antibiotics, especially with higher dosages of aminoglycosides or prolonged therapy.
Monitor prothrombin time.
Perform periodic susceptibility testing when clinically appropriate.
Common
Serious
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Precautions:
AAC 2017;61:e00464-17