항생제
Piperacillin/Tazobactam

Piperacillin/Tazobactam

Medium
N/A

General Information

Broad spectrum agent with anti-pseudomonal activity

Used for severe infections including:

  • Pneumonia
  • Intra-abdominal/hepatobiliary
  • UTI
  • Polymicrobial skin and soft tissue infection
  • Febrile neutropenia

Assess hematopoietic function periodically, including differential.

Monitor electrolytes periodically.

Closely monitor patients with renal impairment or seizure disorders for signs and symptoms of neuromuscular excitability or convulsions.

  • Allergy/rash (immediate or delayed)
  • Cytopenias- esp. thrombocytopenia
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes

Multiple major drug-drug interactions

  • Amifampridine
  • Bupropion
  • Tetracyclines
  • Donepezil
  • Methotrexate
  • Vancomycin
  • Vecuronium
  • Warfarin
  • Cholera vaccine, live

Antimicrobial class: Ureidopenicillin, Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

Precautions:

  • Use caution in patients with renal failure or cystic fibrosis.
  • Use caution in patients requiring sodium restriction.
  • Discontinuation of antibacterial use not directed against Clostridium difficile may be required.
  • Monitoring recommended in prolonged therapy; discontinue if bleeding manifestations occur.
  • Monitoring recommended in patients with renal impairment or seizure disorder.
  • Increased risk of neuromuscular excitability or convulsions with higher than recommended doses.