Typhlitis
Cefepime

Cefepime

High
N/A

General Information

Broad spectrum antimicrobial with gram-positive and gram-negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms.

Monitor WBC count, renal function, prothrombin time.

Common

  • Direct Coombs test positive
  • Rash
  • Diarrhea
  • Hypophosphatemia
  • Increased liver enzymes

Serious

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Clostridium difficile colitis
  • Anaphylaxis
  • Encephalopathy
  • Aphasia
  • Neurotoxicity
  • Myoclonus
  • Nonconvulsive status epilepticus
  • Seizure
  • Warfarin - increased risk of bleeding
  • Cholera vaccine, live

Antimicrobial class: 4th Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

Precautions:

  • Dosage adjustment required in patients with renal impairment (CrCl <60 mL/min).
  • Dosage adjustment or discontinuation may be necessary if neurotoxic events occur.
  • Discontinuation may be necessary in Clostridium difficile-associated diarrhea.
  • Monitoring and dosage adjustment may be necessary in elderly patients, especially with renal dysfunction.