Penicillin G

Penicillin G


General Information

Actinomycotic infection Anthrax Bacteremia, gram-negative Bacterial meningitis Clostridial infection; adjunct Congenital syphilis Diphtheria due to Corynebacterium diphtheriae; treatment and prophylaxis Disseminated gonococcal infection Empyema Fusospirochetosis Infective endocarditis Neurosyphilis Pasteurella infection Pericarditis Pneumonia Rat bite fever Sepsis

During prolong therapy, monitor electrolytes, hepatic and renal functions, hematologic status, cardiac and vascular status.

Perform serologic test for syphilis before initiating therapy for gonococcal infection.

Clinical and serologic follow-up for syphilis treated with penicillin.

  • Allergy/rash (immediate or delayed)
  • Seizures
  • Cytopenias
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • Serum sickness
  • Tetracyclines - decreased antibacterial effectiveness
  • Warfarin - increased risk of bleeding
  • Methotrexate - increased risk of toxicity
  • Seizure agents - reduced seizure threshold

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic