Amphotericin B, Liposomal

제한된
0
C. difficile 위험도
Low
경구생체이용률
N/A

Dosing

Neutropenic feverSystemic fungal infection (aspergillosis, candidiasis, cryptococcosis)Cryptococcal meningitis in HIV-infected patientsVisceral leishmaniasis in immunocompetent patientsVisceral leishmaniasis in immunocompromised patients3 mg/kg IV q24h3-5 mg/kg IV q24h6 mg/kg IV q24h3 mg/kg IV q24h x5d, then 3 mg/kg IV at day 14 & 214 mg/kg IV q24h x5d, then 4 mg/kg IV at day 10, 17, 24, 31, 48No renal dose adjustment

Neutropenic feverSystemic fungal infection (aspergillosis, candidiasis, cryptococcosis)Cryptococcal meningitis in HIV-infected patients3 mg/kg IV q24h3-5 mg/kg IV q24h6 mg/kg IV q24hNo renal dose adjustment

No dose adjustment

General Information

Fungicidal therapy of yeast/fungus/mold infection.

Invasive candidiasis, aspergillosis, cryptococcosis.

Visceral/mucocutaneous Leishmaniasis.

Induction therapy for dimorphic fungii (cocci, blasto, histo).

Not for use in urinary tract infection.

Monitor serum electrolytes, particularly magnesium and potassium.

Evaluate renal and hepatic functions.

Monitor cardiac function in patients using concomitant potassium-depleting agents, including corticosteroids.

Same toxicities as conventional Amphotericin B but with less frequency.

  • Nephrotoxicity ++

  • Anemia

  • Phlebitis

  • Arachnoiditis

  • Urinary retention

  • Paresthesias

Infusion-related symptoms

  • Fever

  • Rigors

  • N/V

  • Headache

Electrolyte abnormalities

  • HypoK and HypoMg

  • Loss of bicarb

  • See additional information

Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.

Increased digoxin toxicity with hypokalemia.

Antimicrobial class: Antifungal, Polyene (Lipid formulations designed to minimize toxicity)

Pregnancy category: B

Average serum half life: 100-153 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor

Lipid associated AmB is taken up preferentially by phagocytic cells and concentrated at sites of infection while minimizing renal exposure.

Premedication with acetaminophen, diphenhydramine, or hydrocortisone are used. Meperidine may be used for rigors.

Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) before and after infusion, as well as K and Mg supplementation PRN.

Terms of Use | Feedback
© Copyright 2021 Spectrum Mobile Health Inc., dba Firstline Clinical. All rights reserved.