Lymphadenitis, bacterial



General Information

Anaerobic infections above the diaphragm, especially dental infection.

Gram-positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta-lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Monitor for diarrhea.

During prolonged therapy, monitor blood count with differential, hepatic and renal functions.


  • Abdominal pain
  • Diarrhea
  • Nausea


  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Erythema multiforme
  • Clostridium difficile colitis
  • Agranulocytosis
  • Muscle relaxants (e.g. atracurium, baclofen, diazepam)
  • St. John's wort

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor