General Spectrum of Activity
Allogeneic hematopoietic stem cell transplant - Cytomegalovirus infection in seropositive patients; Prophylaxis.
Monitor serum creatinine levels in patients with CrCl <50 mL/min receiving IV formulation.
Monitor for reactivation of CMV.
Multiple drug-drug interactions:
Antimicrobial class: Antiviral, Non-nucleoside CMV terminase complex inhibitor
Average serum half life: 12 hours
Not recommended in patients with severe hepatic impairment.
Hydroxypropyl betadex IV vehicle accumulation may occur in patients with IV administration and CrCl <50 mL/min; monitoring recommended.