Cytomegalovirus retinitis Cytomegalovirus infection, Transplantation; Prophylaxis
Black Box Warning: Granulocytopenia, anemia, thrombocytopenia, and pancytopenia have been reported in patients treated with ganciclovir sodium. It may cause temporary or permanent inhibition of spermatogenesis in males and suppression of fertility in females; potential to cause birth defects in humans, and cancers in humans.
Monitor CBC and platelet count, serum electrolytes, serum creatinine and creatinine clearance.
Indirect ophthalmoscopy before therapy initiation, at the end of induction therapy, and at a minimum of every 4-6 weeks during therapy; every 3 months in patients with HIV and immune recovery.
Common
Serious
Antimicrobial class: Antiviral, Nucleoside analog
Pregnancy category: C
Average serum half life: 3.5 hours
Precautions: Use caution in patients with impaired renal function; monitoring and possible dosage reduction recommended.
Use not recommended if absolute neutrophil count <500 cells/mcL or platelet count <25,000 cells/mcL.
Use caution in patients with cytopenias or history of cyptonenic reactions.
항생제
