Ganciclovir

Dosing

Induction 5 mg/kg IV q12h x14-21d

Maintenance 5 mg/kg IV q24h or 6 mg/kg IV 5 times/w

Liver transplant 5 mg/kg IV q12h x7-14d, then 5 mg/kg IV q24h or 6 mg/kg IV 5 times/w (until 100 post-transplant days)

Heart transplant 5 mg/kg IV q12h x14d, then 6 mg/kg IV 5 times/w (until 100-120 post-transplant days)

HSCT patients 5 mg/kg IV q12h x7d, then 5 mg/kg IV q24h (until 100-120 post-transplant days)

Other transplants 5 mg/kg IV q12h x7-14d, then 5 mg/kg IV q24h or 6 mg/kg IV 5 times/w

Safety and efficacy in pediatric patients have not been established

CrCl ≥70CrCl 50-69CrCl 25-49CrCl 10-24CrCl <10, HDNo dose adjustment2.5 mg/kg IV q12h2.5 mg/kg IV q24h1.25 mg/kg IV q24h1.24 mg/kg IV 3 times/w

CrCl ≥70CrCl 50-69CrCl 25-49CrCl 10-24CrCl <10, HDNo dose adjustment2.5 mg/kg IV q24h1.25 mg/kg IV q24h0.625 mg/kg IV q24h0.625 mg/kg IV 3 times/w

General Information

Cytomegalovirus retinitis Cytomegalovirus infection, Transplantation; Prophylaxis

Black Box Warning: Granulocytopenia, anemia, thrombocytopenia, and pancytopenia have been reported in patients treated with ganciclovir sodium. It may cause temporary or permanent inhibition of spermatogenesis in males and suppression of fertility in females; potential to cause birth defects in humans, and cancers in humans.

Monitor CBC and platelet count, serum electrolytes, serum creatinine and creatinine clearance.

Indirect ophthalmoscopy before therapy initiation, at the end of induction therapy, and at a minimum of every 4-6 weeks during therapy; every 3 months in patients with HIV and immune recovery.

Common

  • Sweating

  • Pruritus

  • Diarrhea

  • Vomiting

  • Anemia

  • Neutropenia

  • Thrombocytopenia

  • Neuropathy

  • Blurred vision

  • Eye irritation

  • Conjuctival hyperemia

  • Reduced visual acuity

  • Vitreous hemorrhage

  • Superficial punctate keratitis

  • Fever

Serious

  • Torsades de pointes

  • Stevens-Johnson syndrome

  • GI perforation

  • Pancreatitis

  • Anaphylaxis

  • Sepsis

  • Rhabdomyolysis

  • Retinal detachment

  • Multiple organ failure

  • Imipenem

  • Didanosine

  • Probenecid

  • Tacrolimus

  • Zidovudine

  • Mycophenolate mofetil

Antimicrobial class: Antiviral, Nucleoside analog

Pregnancy category: C

Average serum half life: 3.5 hours

Precautions: Use caution in patients with impaired renal function; monitoring and possible dosage reduction recommended.

Use not recommended if absolute neutrophil count <500 cells/mcL or platelet count <25,000 cells/mcL.

Use caution in patients with cytopenias or history of cyptonenic reactions.

Terms of Use | Feedback
© Copyright 2021 Spectrum Mobile Health Inc., dba Firstline Clinical. All rights reserved.