HIV infection; Adjunct
Perform renal function tests, including estimated CrCl, SCr, and urinalysis with microscopic examination.
Monitor viral load, CD4 cell counts, and hepatitis B screening at baseline and with modification of ARV treatment.
Perform hepatitis C antibody testing prior to initiation or modification of ARV treatment.
Perform hepatic function test in patients with underlying hepatitis B or C viral infections or markedly elevated transaminases.
Monitor ALT, AST, and total bilirubin at baseline and with modification of ARV treatment.
Obtain fasting blood glucose or HbA1C, fasting lipid profile, and CBC with a differential.
Obtain basic chemistry including serum sodium, potassium, bicarbonate, chloride, BUN, creatinine, and creatinine-based estimated glomerular filtration rate.
Common
Serious
Contraindications:
Multiple drug-drug interactions
Antimicrobial class: Antiretroviral, Protease inhibitor
Pregnancy category: Do not initiate
Average serum half life: 7.5 hours (Atazanavir), 3-4 hours (Cobicistat)
Precautions: ECG monitoring should be considered in patients with preexisting conduction-system disease.
Not recommended in treatment-experienced patients with endstage renal disease managed with hemodialysis.
Discontinue use if severe rash develops.
항생제
