항생제
Praziquantel

Praziquantel

Spectrum Of Activity

General Information

  • Schistosomiasis
  • Clonorchiasis
  • Infection by Opisthorchis viverrini

Monitor patients with preexisting cardiac arrhythmias.

Monitor for adverse reactions when administering the recommended dose in hepatosplenic schistosomiasis patients with moderate or severe liver impairment.

Common

  • Abdominal pain
  • Nausea
  • Vomiting
  • Dizziness
  • Fever

Serious

  • Cardiac dysrhythmia
  • CNS complication
  • Seizure
  • Jarisch Herxheimer reaction
  • Hypersensitivity reaction

Contraindication:

  • CYP450 inducers
  • Rifampin
  • Phenytoin
  • Carbamazepine
  • Phenobarbital
  • Dexamethasone

Antimicrobial class: Anthelmintic agent, Pyrazino-isoquinoline

Pregnancy category: B

Average serum half life: 08-1.5 hours

Precautions: Use not recommended for exacerbation of CNS pathology unless benefit outweighs risk.

Risk of toxicity may be increased in patients with renal impairment.

Hepatosplenic schistosomiasis with moderate to severe liver impairment at increased risk of toxicity.