Praziquantel

Dosing

Schistosomiasis 20 mg/kg PO at 0, 4-6, 10-12h

Clonorchiasis, opisthorchiasis 25 mg/kg PO at 0, 4-6, 10-12h

Cysticercosis 50 mg/kg PO #3 q8h x14d

Paragonimiasis 25 mg/kg PO q8h x2d

Tapeworm infestation 5-10 mg/kg PO (1 dose) No renal dose adjustment

Safety and efficacy in pediatric patients <4y have not been established

Age ≥4y Refer to adult dose No renal dose adjustment

No dose adjustment

General Information

  • Schistosomiasis

  • Clonorchiasis

  • Infection by Opisthorchis viverrini

Monitor patients with preexisting cardiac arrhythmias.

Monitor for adverse reactions when administering the recommended dose in hepatosplenic schistosomiasis patients with moderate or severe liver impairment.

Common

  • Abdominal pain

  • Nausea

  • Vomiting

  • Dizziness

  • Fever

Serious

  • Cardiac dysrhythmia

  • CNS complication

  • Seizure

  • Jarisch Herxheimer reaction

  • Hypersensitivity reaction

Contraindication:

  • CYP450 inducers

  • Rifampin

  • Phenytoin

  • Carbamazepine

  • Phenobarbital

  • Dexamethasone

Antimicrobial class: Anthelmintic agent, Pyrazino-isoquinoline

Pregnancy category: B

Average serum half life: 08-1.5 hours

Precautions: Use not recommended for exacerbation of CNS pathology unless benefit outweighs risk.

Risk of toxicity may be increased in patients with renal impairment.

Hepatosplenic schistosomiasis with moderate to severe liver impairment at increased risk of toxicity.

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