Ivermectin

Dosing

Infection by Onchocerca volvulus, non-adult stage 150 mcg/kg PO (1 dose); re-treatment intervals 3 and 12m

Infestation by Phthirus pubis 250 mcg/kg PO (1 dose) with food; repeat in 14d

Intestinal strongyloidiasis 200 mcg/kg PO (1 dose)

  • If evidence of larvae still present during 3m following treatment, retreat with single dose

Scabies 200 mcg/kg PO (1 dose) with food; repeat in 2w

Pediculosis capitis 0.5% lotion, apply up to 1 tube topically to dry hair

  • Rinse after 10min

Rosacea, Inflammatory lesions 1% cream, apply thin film topically once dailyNo data on renal dose adjustment

Safety and efficacy of oral Ivermectin in pediatric patients BW <15 kg have not been established

Infection by Onchocerca volvulus, non-adult stage BW ≥15 kg 150 mcg/kg PO (1 dose); re-treatment intervals 3 and 12m

Intestinal strongyloidiasis BW ≥15 kg 200 mcg/kg PO (1 dose)

  • If evidence of larvae still present during 3m following treatment, retreat with single doseNo data on renal dose adjustment

General Information

  • Infection of Onchocerca volvulus, non-adult stage

  • Intestinal strongyloidiasis

  • Pediculosis capitis

  • Rosacea, Inflammatory lesions

Off-label

  • Ascariasis

  • Cutaneous larva migrans

  • Enterobiasis

  • Infection by Loa loa

  • Infection by Wuchereria bancrofti

  • Infestation by Phthirus pubis

  • Mansonelliasis

  • Scabies

Strongyloidiasis: Obtain 1 stool culture per month for 3 months following treatment.

Onchocerciasis: Perform ophthalmic exam at baseline and periodically during treatment. Assess for loiasis prior to treatment with history of significant exposure to Loa loa-endemic areas.

Common

  • Pruritus

  • Urticaria

  • Dizziness

Serious

  • Mazzotti reaction

  • Seizure

Warfarin- may elevate INR values

Antimicrobial class: Anthelmintic agent, Avermectin

Pregnancy category: C

Average serum half life: 18 hours (oral), 6.5 days (topical)

Precautions: Patients with onchocerciasis may have cutaenous, allergic and inflmmatory systemic, and ophthalmological reactions during oral use.

In patients with exposure to Loa loa endemic areas, pretreatment assessment for loiasis and careful monitoring is recommended.

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