Measure peak (30-90 minutes after injection) and trough (just prior to the next dose) kanamycin serum concentrations intermittently during therapy.
Obtain acid-fast bacilli (AFB) smear and culture from sputum at least monthly until 2 consecutive culture specimens are negative.
Perform chest x-rays after 2 to 3 months of treatment in patients with negative initial cultures and at end of treatment.
Obtain serial audiograms and monitor vestibular function.
Monitor renal function; urine.