Spectrum Of Activity
100 mg PO twice daily x24w
- In combination with multidrug-resistant TB regimen
Safety and effectiveness in pediatric patients <18y of age have not been established
Mild hepatic impairment No dose adjustment
Severe hepatic impairment Not recommended
Mild or moderate renal impairment No dose adjustment
Severe renal impairment Not recommended
Multidrug resistant respiratory tuberculosis, use only in combination with other agents.
Directly observed therapy (DOT) is recommended.
Obtain serum electrolytes at baseline.
Obtain ECG prior to treatment and monthly; monitoring if QTc interval exceeds 500 msec before or during treatment.
Decrease in appetite
Upper abdominal pain
Prolonged QT interval
QT interval prolonging drugs
Antimicrobial class: Antimycobacterial, Nitroimidazole
Pregnancy category: Not recommended
Average serum half life: 30-38 hours
Precautions: QT prolongation slowly increases during the first 6-10 weeks of treatment; monitoring recommended; discontinue use if QTcF >500 msec occurs.
Avoid use in patients with electrolyte disturbances, especially hypokalemia, hypocalcemia or hypomagnesemia; monitor frequently if use is unavoidable.