Multidrug resistant respiratory tuberculosis, use only in combination with other agents.
Directly observed therapy (DOT) is recommended.
Obtain serum electrolytes at baseline.
Obtain ECG prior to treatment and monthly; monitoring if QTc interval exceeds 500 msec before or during treatment.
Common
Serious
Contraindications:
Antimicrobial class: Antimycobacterial, Nitroimidazole
Pregnancy category: Not recommended
Average serum half life: 30-38 hours
Precautions: QT prolongation slowly increases during the first 6-10 weeks of treatment; monitoring recommended; discontinue use if QTcF >500 msec occurs.
Avoid use in patients with electrolyte disturbances, especially hypokalemia, hypocalcemia or hypomagnesemia; monitor frequently if use is unavoidable.
항생제
