Monitor CBC weekly for first month then monthly for 6 months.
Monitor liver function at baseline, then periodically throughout therapy.
In HIV patients, monitor CBC platelets and reticulocyte counts, every 2-3 days during first 2-3 weeks, then monthly for the first 3 months, and then every 6 months.
Common
Serious
Antimicrobial class: Sulfone
Pregnancy category: C
Average serum half life: 10-50 hours (average 28 hours)
Precautions: Dose-related hemolytic anemia, hemolysis and hepatotoxic reactions have been reported with oral treatment, especially in individuals with G6PD deficiency; discontinue if signs and symptoms occur.
Discontinue if new or toxic skin reactions occur.
Monitoring recommended and discontinue if significant reduction in leukocytes, platelets, or hemopoiesis occurs.
Treat severe anemia prior to oral dapsone initiation; monitoring recommended.
항생제
