Cycloserine

Dosing

Usual dose 250-500 mg PO q12h (max 1 g/d)

Usual dose 5-10 mg/kg PO q12h

No dose adjustment

CrCl >50CrCl 10-50CrCl <10No dose adjustment250-500 mg PO q24h250 mg PO q24h

General Information

  • Tuberculosis

  • Urinary tract infectious disease

Monitor serum drug levels periodically to maintain blood levels <30 mcg/mL.

Monitor renal and liver functions periodically.

Obtain hematologic panels periodically.

Monitor closely for CNS toxicity in patients receiving total dialy dose >500 mg.

Assess neruospychiatric statust at least monthly.

Common

  • Confusion

  • Dizziness

  • Headache

  • Somnolence

Serious

  • Seizure

Ethionamide- increased risk of seizures

Antimicrobial class: Antitubercular, d-alanine analog

Pregnancy category: C

Average serum half life: 10-25 hours

Precautions:

  • CNS toxicity may occur; discontinue if condition develops.

  • Discontinue if allergic dermatitis develops.

  • Chronic alcoholics have an increased risk for convulsions.

  • Contraindicated in patients with epilepsy, depression, severe anxiety, psychosis, severe renal insufficiency, and excessive use of alcohol.

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