항생제
Clofazimine

Clofazimine

Spectrum Of Activity

General Information

  • Lepromatous leprosy, Dapsone-resistant
  • Lepromatous leprosy, Dapsone-sensitive
  • Type 2 lepra reaction

Obtain a pregnancy test prior to initiation in sexually active women of reproductive potential.

Monitor for depression or suicidal ideation, which may occur due to skin discoloration.

Common

  • Diarrhea
  • Epigastric pain
  • Nausea
  • Vomiting
  • Abdominal pain
  • Skin discoloration

Serious

  • Prolonged QT interval
  • Torsades de pointes
  • Bowel obstruction
  • GI hemorrhage
  • Splenic infarction
  • Psychiatric effects

Contraindication:

  • QT interval prolonging drugs
  • Mesoridazine
  • Ziprasidone
  • Saquinavir
  • Sparfloxacin
  • Bepridil
  • Terfenadine
  • Piperaquine
  • Thioridazine
  • Pimozide
  • Dronedarone
  • Cisapride

Major drug-drug interactions:

  • QT prolonging drugs
  • Bedaquiline
  • Phenytoin
  • Citalopram

Antimicrobial class: Leprostatic

Pregnancy category: C

Average serum half life: 25 days

Precautions: Monitoring recommended for pschiatric symptoms.

Investigate abdominal symptoms; dose reduction or discontinuation may be necessary.

Monitoring recommended when using in combination with other QT prolonging drugs.