Multidrug resistant tuberculosis, in combination with at least 3 other agents.
Obtain sputum for mycobacterial culture and susceptibility testing prior to and during treatment.
Monitor liver function tests at baseline and during treatment.
Measure serum calcium, magnesium, and potassium at baseline.
Monitor ECG before initiation and during treatment.
Common
Serious
Multiple drug-drug interactions
Antimicrobial class: Diarylquinoline
Pregnancy category: B
Average serum half life: 24-30 hours (effective) 4-5 months (terminal)
Precautions: Monitoring recommended and discontinue use with appearance of a clinically significant ventricular arrhythmia or a QTc interval of greater than 500 milliseconds (confirmed by repeat ECG).
Monitoring recommended and discontinue use if aminotransferase elevations are greater than 8 times ULN, or are greater than 5 times ULN and persist beyond 2 weeks, or are accompanied by total bilirubin greater than 2 times ULN.
항생제
