Spectrum Of Activity
Aspergillosis, invasive Mucormycosis, invasive
Loading: 372 mg PO (2 capsules) or IV q8h for 6 doses
Maintenance: 372 mg PO (2 capsules) or IV once daily, starting 12-24h after last loading dose
Duration: 6-12w depending on disease
Available in bioequivalent oral and IV formulations; may switch between formulations.No renal dose adjustment
Safety and efficacy in pediatric patients <18y of age have not been established
No dose adjustment
Evaluate liver function tests at the beginning of and during treatment.
Monitor adverse reactions in patients with severe hepatic impairment.
Increased liver function test
Acute respiratory failure
Major drug-drug interactions:
P-gp and CYP3A4 substrates with narrow therapeutic index
Antimicrobial class: Antifungal, Triazole
Pregnancy category: May cause fetal harm
Average serum half life: 130 hours (Isavuconazole)
Precautions: Discontinue if severe cutaneous reaction develops.
Use cautiously in patients with hypersensitivity to other azole antifungals.
Hypotension, dyspnea, chills, dizziness, paraesthesia, hypoesthesia have been reported during IV administration; discontinue.