항생제
Isavuconazonium

Isavuconazonium

Spectrum Of Activity

General Information

  • Aspergillosis, invasive
  • Mucormycosis, invasive

Evaluate liver function tests at the beginning of and during treatment.

Monitor adverse reactions in patients with severe hepatic impairment.

Common

  • Peripheral edema
  • Hypokalemia
  • Diarrhea
  • Constipation
  • Nausea
  • Vomiting
  • Backache
  • Cough
  • Headache
  • Dyspnea

Serious

  • Cholestasis
  • Hepatitis
  • Increased liver function test
  • Liver failure
  • Renal failure
  • Acute respiratory failure
  • Infusion reaction
  • Hypersensitivity reaction

Contraindications:

  • CYP3A4 inducers/inhibitors
  • Ritonavir
  • Itraconazole
  • Mephobarbital

Major drug-drug interactions:

  • Lopinavir
  • P-gp and CYP3A4 substrates with narrow therapeutic index
  • Mycophenolate mofetil
  • Midazolam
  • Atorvastatin

Antimicrobial class: Antifungal, Triazole

Pregnancy category: May cause fetal harm

Average serum half life: 130 hours (Isavuconazole)

Precautions: Discontinue if severe cutaneous reaction develops.

Use cautiously in patients with hypersensitivity to other azole antifungals.

Hypotension, dyspnea, chills, dizziness, paraesthesia, hypoesthesia have been reported during IV administration; discontinue.