Black Box Warning: Itraconazole can cause or exacerbate congestive heart failure (CHF). Itraconazole oral capsules and tablets should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF).
Monitor liver function tests; signs and symptoms of peripheral neuropathy.
Evaluate signs and symptoms of congestive heart failure (CHF), especially in patients with preexisting risk factors.
Obtain fungal cultures prior to initiation.
Common
Serious
Contraindications:
Multiple drug-drug interactions
Antimicrobial class: Antifungal, Triazole
Pregnancy category: C
Average serum half life: 16-28 hours (single dose), 34-42 hours (repeated dosing)
Precautions: Discontinuation may be warranted if increased risk of CHF with ischemic and valvular disease, pulmonary disease, renal failure, or edematous disorders.
Not recommended in patients with hepatic impairment and those at risk of systemic candidiasis.
Discontinue use if neuropathy or hepatotoxicity occurs.
Avoid use in geriatric patients unless benefit outweighs risk.