Zabofloxacin

Dosing

1 tab (366.69 mg) PO once daily x5d

Safety and efficacy in pediatric patients <18y of age have not been established

Mild renal impairment No dose adjustment

Moderate to severe renal impairment No data

General Information

  • Acute exacerbation of chronic obstructive pumonary disease (COPD)

  • Chronic bronchitis

  • Emphysema

Zabofloxacin is used for patients who do not have other treatment options.

  • Anaphylactic shock

  • CNS effects

  • Psychosis

  • Clostridium difficile associated diarrhea

  • Abdominal pain

  • Diarrhea

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Al or Mg-containing antacids

  • Fe-containing agents

  • Ca-containing agents

  • Zn or Fe-containing multivitamins

  • Theophylline

  • Warfarin

Increase the risk of central nervous irritation and convulsive seizures

  • Quinolone antibacterial agents

  • NSAIDs (i.e. phenylacetic acid, propionic acid)

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Associated with disability and potentially irreversible serious adverse reactions with the following symptoms:

  • Tendinitis and tendon rupture

  • Peripheral neuropathy

  • Central nervous system effect

  • May be more severe in patients with myasthenia gravis

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