Tosufloxacin

Dosing

300-450 mg/d PO #2-3 (max 600 mg/d)

Safety and efficacy in pediatric patients <18y of age have not been established

No dose adjustment

Renal impairment Use with caution

General Information

  • Community-acquired pneumonia

  • Diffuse panbronchiolitis

  • Chronic bronchitis

  • Bronchiectasis (in case of infection)

  • Secondary infection of chronic respiratory disease

  • Otitis media

  • Sinusitis

  • Purulent salivitis/ Purulent sialadenitis

  • Periodontitis

  • Pericoronitis

  • Pyelonephritis

  • Cystitis

  • Prostatitis

  • Epididymitis

  • Urethritis

  • Bacillary dysentery

  • Infectious enteritis

  • Cholecystitis

  • Cholangitis

  • Skin infections

  • Intrauterine infection

  • Adnexitis

  • Bartholinitis

  • Sty

Monitor renal function.

  • Nausea

  • Vomiting

  • Diarrhea

  • Abdominal pain

  • Constipation

  • Loss of appetite

  • Tendonitis

  • Tendon rupture

  • Peripheral neuropathy

  • Myasthenia gravis

  • Fever

  • Interstitial nephritis

  • Acute renal failure

  • Increased liver enzymes

  • Jaundice

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Anemia

  • Agranulocytosis

  • Thrombocytopenia

  • Leukopenia

  • Eosinophilia

  • Headache

  • Seizures

  • Psychosis

  • Epilepsy

  • Aortic aneurysm

  • Hypersensitivity reaction

  • Theophylline

  • Aminophylline

  • Cholinetheophylline

  • Phenylacetic acid

  • Propionic acid-based NSAIDs (i.e. Fenbufen)

  • Antacid containing Al or Mg

  • Fe-containing agents

  • Ca-containing agents

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Precautions: Do not administer to patients with a history of myasthenia gravis.

Among patients receiving quinolone antibiotics such as levofloxacin, tendon ruptures have been reported. This risk increases with the elderly, patients with renal impairment, organ transplantation, or in combination with corticosteroids.

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