Hepatic encephalopathy, Prophylaxis 550 mg PO twice daily

Irritable bowel syndrome with diarrhea 550 mg PO 3 times daily x14d

  • May repeat up to 2 times with the same dose regimen

Traveler's diarrhea, Noninvasive strains of E. coli 200 mg PO 3 times daily x3d

Age ≥12y 200 mg PO 3 times daily x3d

No dose adjustment

General Information

  • Hepatic encephalopathy; Prophylaxis.

  • Irritable bowel syndrome (with diarrhea).

  • Traveler's diarrhea, Noninvasive strains of E. coli.

Evaluate for Clostridium-associated diarrhea if diarrhea occurs after treatment or does not improve during treatment.


  • Peripheral edema

  • Abdominal pain

  • Nausea

  • Dizziness

  • Ascites

  • Fatigue

  • Headache


  • Anemia

  • Hypersensitivity reaction

  • Cholera vaccine, live

  • Lixisenatide

  • Warfarin- potential effect on INR

Antimicrobial class: Rifamycin

Pregnancy category: C

Average serum half life: 2-5 hours

CSF penetration: Poor

Precautions: Use with caution in patients with severe (Child-Pugh Class C) hepatic impairment due to increased systemic exposure.

Rifaximin was not effective in diarrhea complicated by fever and/or blood in the stool or diarrhea due to pathogens other than E. coli. If diarrhea symptoms get worse or persist for more than 24-48 hours, discontinue and consider alternative antibiotics.

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