Spectrum Of Activity
Hepatic encephalopathy, Prophylaxis 550 mg PO twice daily
Irritable bowel syndrome with diarrhea 550 mg PO 3 times daily x14d
- May repeat up to 2 times with the same dose regimen
Traveler's diarrhea, Noninvasive strains of E. coli 200 mg PO 3 times daily x3d
Age ≥12y 200 mg PO 3 times daily x3d
No dose adjustment
Hepatic encephalopathy; Prophylaxis.
Irritable bowel syndrome (with diarrhea).
Traveler's diarrhea, Noninvasive strains of E. coli.
Evaluate for Clostridium-associated diarrhea if diarrhea occurs after treatment or does not improve during treatment.
Cholera vaccine, live
Warfarin- potential effect on INR
Antimicrobial class: Rifamycin
Pregnancy category: C
Average serum half life: 2-5 hours
CSF penetration: Poor
Precautions: Use with caution in patients with severe (Child-Pugh Class C) hepatic impairment due to increased systemic exposure.
Rifaximin was not effective in diarrhea complicated by fever and/or blood in the stool or diarrhea due to pathogens other than E. coli. If diarrhea symptoms get worse or persist for more than 24-48 hours, discontinue and consider alternative antibiotics.