Piperacillin/Sulbactam

Dosing

300 mg/kg IV once daily (4 divided doses)

  • Equivalent to Piperacillin 200 mg/Sulbactam 100 mg

Safety and efficacy in pediatric patients ≤12y of age have not been established

Severe renal impairment Use with caution

General Information

  • Sepsis

  • Acute chronic bronchitis

  • Empyema

  • Pneumonia

  • Lung abscess

  • Pyelonephritis

  • Cystitis

  • Endometritis

  • Bronchiecstasis

  • Secondary infection of chronic respiratory disease

  • Urethritis

  • Peritonitis

  • Abscess (intraabdominal, pelvic)

  • Salpingitis

  • Skin and soft tissue infections

  • Cholangitis

  • Aerobic and anerobic infections

Perform liver and renal function tests, and blood counts regularly.

Perform skin reaction test prior to treatment.

Perform electrolyte tests in patients receiving cyottoxin therapy or diuretics.

  • Headache

  • Dizziness

  • Fatigue

  • Diarrhea

  • Abdominal pain

  • Vomiting

  • Nausea

  • Increased liver enzymes

  • Hyperbilirubinemia

  • Hepatitis

  • Leukopenia

  • Neutropenia

  • Thrombocytopenia

  • Agranulocytosis

  • Anemia

  • Eosinophilia

  • Phlebothrombitis

  • Erythema

  • Renal failure

  • Fever

  • Rash

  • Urticaria

  • Itching

  • Stevens-Johnson syndrome

  • Hypersensitivity reaction

  • Aminoglycosides

  • Ammonium-based muscle nerve blockers (i.e. Vecuronium)

  • Methotrexate

Precautions: Severe anaphylactic reactions have been reported in patients receiving penicillin-based drugs.

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