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항생제
Imipenem/Cilastatin

Imipenem/Cilastatin

Spectrum Of Activity

General Spectrum of Activity
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General Information

  • Bacterial sepsis
  • Female genital infection
  • Bone infection - Infectious disorder of joint
  • Infection of skin and/or subcutaneous tissue
  • Infectious disease of abdomen
  • Infective endocarditis due to Staphylococcus aureus
  • Lower respiratory tract infection
  • Urinary tract infectious disease

Perform renal, hepatic, and hematopoietic function tests.

Susceptibility testing in patients with Pseudomonas aeruginosa infections.

Common

  • Phlebitis
  • Rash
  • Diarrhea
  • Nausea
  • Vomiting
  • Thrombophlebitis

Serious

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • C. difficile diarrhea
  • Seizure
  • Hypersensitivity reaction
  • Imipenem- may result in CNS toxicity
  • Valproic acid
  • Valganciclovir
  • Theophylline
  • Cholera vaccine, live

Antimicrobial class: Carbapenem

Pregnancy category: C

Average serum half life: 1 hour

Intermediate testing:

  • Enterobacteriaceae, MIC of 2 mcg/mL
  • Pseudomonas aeruginosa, MIC of 4 mcg/mL
  • Acinetobacter species, MIC of 4 mcg/mL
  • Anaerobes, MIC of 8 mcg/mL

Precautions:

  • Discontinue if Clostridium difficile-associated diarrhea or allergic reaction occurs.
  • Renal impairment increases the risk for CNS adverse events. Not recommended in patients on HD unless benefits outweighs potential risk of seizures.
  • Not recommended in children with CNS infections due to increased risk of seizure.