Cefotiam

Dosing

Usual dose 2-8 g/d IV (2-4 divided doses)

Urinary tract infection 1 g IV q12h

40-80 mg/kg/d IV #3-4

(Increased to 160 mg/kg/d for severe intractable infections such as sepsis and meningitis)

No dose adjustment

CrCl <2075% recommended dose IV q6-8h

General Information

  • Gonorrhea

  • Pharyngitis - Sinusitis

  • Postoperative infection; Prophylaxis

  • Respiratory tract infection

  • Soft tissue infection

  • Urinary tract infectious disease

Perform renal function tests, such as BUN and serum creatinine.

Monitor blood cell count, and repeat culture and sensitivities if necessary.

Monitor decrease in temperature; signs of severe allergic reaction.

  • Phlebitis

  • Thrombophlebitis

  • Contact dermatitis

  • Rash

  • Neutropenia

  • Hypoprothrombinemia

  • Hepatotoxicity

  • Urticaria

  • Hypersensitivity reaction

  • Anaphylaxis

  • Cholera vaccine, live

  • Typhoid vaccine, live

Antimicrobial class: 2nd Generation Cephalosporin

Average serum half life: 0.6-1.1 hour

Urine penetration: Moderate

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