Cefdinir

Dosing

Bronchitis, chronic, acute bacterial exacerbation 300 mg PO q12h x5-10d or 600 mg PO once daily x10d

Community-acquired pneumonia 300 mg PO q12h x10d

Skin and/or subcutaneous tissue, uncomplicated 300 mg PO q12h x10d

Maxillary sinusitis, acute 300 mg PO q12h or 600 mg PO q24h x10d

Pharyngitis - Tonsillitis 300 mg PO q12h x5-10d or 600 mg PO q24h x10d

Acute otitis media Age 6m-12y 14 mg/kg/d PO (1 or 2 divided doses) x5-10d

Bronchitis, chronic, acute bacterial exacerbation Age ≥13y 300 mg PO q12h x5-10d or 600 mg PO once daily x10d

Community-acquired pneumonia Age ≥13y 300 mg PO q12h x10d

Skin and/or subcutaneous tissue, uncomplicated Age 6m-12y 7 mg/kg PO q12h x10d (max 600 mg/d)

Age ≥13y 300 mg PO q12h x10d

Maxillary sinusitis, acute Age ≥6m 7 mg/kg PO q12h x10d or 14 mg/kg PO once daily x10d (max 600 mg/d)

Age ≥13y 300 mg PO q12h or 600 mg PO q24h x10d

Pharyngitis - Tonsillitis Age 6m-12y 7 mg/kg PO q12h x5-10d or 14 mg/kg PO once daily x10d (max 600 mg/d)

Age ≥13y 300 mg PO q12h x5-10d or 600 mg PO q24h x10d

CrCl <30300 mg PO once daily

CrCl <30 mL/min/1.73 m(2)7 mg/kg once daily (up to 300 mg/d)

HD300 mg or 7 mg/kg PO every other day, and at then end of each HD session

General Information

  • Acute otitis media

  • Bronchitis, chronic, acute bacterial exacerbation

  • Community-acquired pneumonia

  • Skin and/or subcutaneous tissue infection, uncomplicated

  • Maxillary sinusitis, acute

  • Pharyngitis - Tonsillitis

Monitor fever; CBC; symptomatic improvement; hepatic and renal functions.

Monitor previous hypersensitivity to other beta-lactam antibiotics.

Monitor signs of serum-sickness-like reactions, and antibiotic-associated diarrhea.

Common

  • Diarrhea

  • Abdominal pain

  • Nausea

  • Candida vaginitis

Serious

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Clostridium difficile colitis

  • Hepatitis

  • Hepatotoxicity

  • Hypersensitivity reaction

  • Warfarin- increased risk of bleeding

  • Cholera vaccine, live

  • Combination oral contraceptives

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.7 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Precautions: Dose reduction recommended in patients with renal insufficiency.

Emergence and overgrowth of resistant pathogens may occur with prolonged therapy; close observation recommended; alternative therapy is required if superinfection occurs.

Use with caution in patients with history of colitis and penicillin hypersensitivity.

Oral suspension contains sucrose and should be used with caution in patients with diabetes.

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