Monitor infusion rate to prevent thrombophlebitis.

Monitor status of elderly patients due to risk of hemorrhage.

Perform skin reaction test prior to treatment.

Monitor renal function, especially in severe patients receiving maximum dose.

• Rash
• Hives
• Erythema
• Itchiness
• Fever
• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Abdominal pain
• Seizure
• Hypoprothrombinemia
• Abnormal liver function
• Hypersensitivity reaction
• Anaphylaxis (rare)

• Furosemide- may increase nephrotoxicity
• Aminoglycoside
• Cephalosporin
• Probenecid