Cefaclor

Dosing

Mild to moderate infection 250 mg PO q8h

Severe infection (pneumonia) 500 mg PO q8h

(max 6 g/d, if severe)No renal dose adjustment

Safety and efficacy in pediatric patients <1m of age have not been established

Mild to moderate infection 20 mg/kg PO #3

Severe infection (otitis media) 40 mg/kg PO #3 (max 1 g/d)No renal dose adjustment

No dose adjustment

General Information

  • Acute bacterial exacerbation of chronic bronchitis

  • Acute otitis media

  • Bronchitis, acute- Secondary bacterial infection

  • Infection of skin and/or subcutaneous tissue

  • Lower respiratory tract infection

  • Pharyngitis

  • Tonsillitis

  • Urinary tract infectious disease

Monitor fever, CBC, previous hypersensitivity to other beta-lactam antibiotics, hypersensitivity to other beta-lactam antibiotics, signs of antibiotic-associated diarrhea and serum-sickness-like reactions.

Monitor liver and renal functions.

Common

  • Diarrhea

Serious

  • Stevens-Johnson sydrome

  • Toxic epidermal necrolysis

  • Clostridium difficile colitis

  • Hemolytic anemia

  • Serum sickness

Drug-drug interactions:

  • Teriflunomide

  • Leflunomide

  • Cholera vaccine, live

  • Combination oral contraceptives

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 0.8 hour

Precautions: Discontinuation may be required in Clostridium difficile-associated diarrhea.

Use caution in patients with history of gastrointestinal disease particularly colitis; hypersensitivity to penicillins; renal impairment.

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